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Company · IONS

Ionis Pharmaceuticals, Inc.

Name as listed on its exchange; filed with the SEC as IONIS PHARMACEUTICALS INC.

Nasdaq's symbol directory lists IONS on Nasdaq as “Ionis Pharmaceuticals, Inc. - Common Stock”.

In the 12 months to Nov 8, 2026: insiders bought on 2 occasions ($1.1M); insiders sold on 15 occasions ($19.1M); 1 planned-sale notice; 3 company reports (Form 8-K, since May 26, 2026).

All insider filings at the SEC

Insider purchases and sales, by month (last 12 months)Insider purchases: $1.1M in total; Insider sales: $19.1M in total.Jun: Insider sales $15.5MJul: Insider purchases $1.1MJul: Insider sales $3.5MOct: Insider sales $61KDecJanFebMarAprMayJunJulAugSepOctNov
Insider purchases above the line: $1.1MInsider sales below: $19.1M
Dollar value of open-market purchases and sales reported on SEC Form 4, by the month traded. Sales include pre-arranged 10b5-1 plan sales.

Insider trades · SEC Form 4

Those inside the hall

Open-market purchases and sales only. Legs one person filed for one day are combined.

Who traded

  1. Brett P. Monia, Chief Executive Officer sold on 3 days all under a 10b5-1 plan latest Jun 26, 2026 sold $6.8M
  2. Holly B. Kordasiewicz, EVP, Chief Development Officer sold on 2 days all under a 10b5-1 plan latest Jul 7, 2026 sold $4.5M
  3. Eugene Schneider, EVP, Chf Clinical Develop Ofcr sold on 1 day all under a 10b5-1 plan latest Jun 26, 2026 sold $2.1M
  4. C. Frank Bennett, EVP, Chief Scientific Officer sold on 1 day all under a 10b5-1 plan latest Jul 7, 2026 sold $1.7M
  5. Hayden Michael R bought on 2 days latest Jul 31, 2026 bought $1.1M
  6. KLEIN JOSEPH III sold on 1 day all under a 10b5-1 plan latest Jul 1, 2026 sold $910K
  7. Diaz Allene M. sold on 1 day all under a 10b5-1 plan latest Jul 7, 2026 sold $864K
  8. Swayze Eric, EVP Research sold on 2 days 1 of them under a 10b5-1 plan latest Oct 16, 2026 sold $842K
  9. BERTHELSEN SPENCER R sold on 1 day all under a 10b5-1 plan latest Jun 15, 2026 sold $588K
  10. Baroldi Joseph, EVP, Chief Business Officer sold on 1 day all under a 10b5-1 plan latest Jun 26, 2026 sold $452K

and 2 more people.

Every trade (17)
  1. SELLDevers Shannon L., EVP, Chief Human Resources Ofc sold Oct 16, 2026 1,357 shares filing $59K
  2. SELLSwayze Eric, EVP Research sold Oct 16, 2026 53 shares filing $2K
  3. BUYHayden Michael R bought Jul 31, 2026 5,000 shares filing $258K
  4. BUYHayden Michael R bought Jul 30, 2026 15,000 shares filing $801K
  5. SELLC. Frank Bennett, EVP, Chief Scientific Officer sold Jul 7, 2026 20,536 shares 2 legs combined 10b5-1 plan (scheduled) filing $1.7M
  6. SELLDiaz Allene M. sold Jul 7, 2026 10,111 shares 10b5-1 plan (scheduled) filing $864K
  7. SELLHolly B. Kordasiewicz, EVP, Chief Development Officer sold Jul 7, 2026 362 shares 10b5-1 plan (scheduled) filing $31K
  8. SELLKLEIN JOSEPH III sold Jul 1, 2026 11,518 shares 2 legs combined 10b5-1 plan (scheduled) filing $910K
  9. SELLBrett P. Monia, Chief Executive Officer sold Jun 26, 2026 50,000 shares 10b5-1 plan (scheduled) filing $4.0M
  10. SELLEugene Schneider, EVP, Chf Clinical Develop Ofcr sold Jun 26, 2026 26,000 shares 10b5-1 plan (scheduled) filing $2.1M
  11. SELLBaroldi Joseph, EVP, Chief Business Officer sold Jun 26, 2026 5,635 shares 10b5-1 plan (scheduled) filing $452K
  12. SELLO'NEIL PATRICK R., EVP CLO & General Counsel sold Jun 26, 2026 3,069 shares 10b5-1 plan (scheduled) filing $246K
  13. SELLBrett P. Monia, Chief Executive Officer sold Jun 25, 2026 21,072 shares 10b5-1 plan (scheduled) filing $1.7M
  14. SELLSwayze Eric, EVP Research sold Jun 25, 2026 10,602 shares 10b5-1 plan (scheduled) filing $839K
  15. SELLBrett P. Monia, Chief Executive Officer sold Jun 24, 2026 14,565 shares 10b5-1 plan (scheduled) filing $1.1M
  16. SELLBERTHELSEN SPENCER R sold Jun 15, 2026 8,000 shares 10b5-1 plan (scheduled) filing $588K
  17. SELLHolly B. Kordasiewicz, EVP, Chief Development Officer sold Jun 12, 2026 60,846 shares 2 legs combined 10b5-1 plan (scheduled) filing $4.5M

Planned sales · SEC Form 144

Notice given

A Form 144 is filed before an insider sells restricted stock. It states an intent; the sale, if it happens, appears later on a Form 4. Every recent notice

  1. Devers Shannon L. filed Oct 16, 2026 Officer 1,357 shares planned sale date 10/16/2026 filing $60K

Company reports · SEC Form 8-K

In its own words

Current reports the company filed with the SEC; most items are due within four business days of the event. Each line lists the report's items by the SEC's own titles; the filing says what happened. Reports collected since May 26, 2026; every 8-K at the SEC.

  1. Regulation FD disclosure; Other events filing Oct 23, 2026
  2. Regulation FD disclosure; Other events filing Oct 21, 2026
  3. Regulation FD disclosure; Other events filing Sep 23, 2026

Sources: SEC EDGAR (Forms 4, 144 and 8-K) and STOCK Act periodic transaction reports. Filings can be late, amended or wrong at the source; see methodology.