LYTIR

Insider · SEC Form 4 · Director, 10% Owner

RA CAPITAL MANAGEMENT, L.P.

In the 12 months to Nov 8, 2026, on the open market: bought $489.0M of PBLS, BBTX, ARTV and 1 more; sold $94.7M of SEPN, SION, LENZ and 1 more. Filed a median of 2 business days after the trade.

Open-market purchases and sales this filer reported on SEC Form 4, by the day traded. Insiders have two business days to file. A sale marked 10b5-1 was made under a plan adopted in advance. How to read these

Insider purchases and sales, by month (last 12 months)Insider purchases: $489.0M in total; Insider sales: $94.7M in total.Jun: Insider purchases $430.4MJun: Insider sales $320KJul: Insider purchases $12.0MAug: Insider sales $63.5MSep: Insider sales $21.8MOct: Insider purchases $6.6MOct: Insider sales $9.1MNov: Insider purchases $40.0MDecJanFebMarAprMayJunJulAugSepOctNov
Insider purchases above the line: $489.0MInsider sales below: $94.7M
Dollar value of open-market purchases and sales reported on SEC Form 4, by the month traded. Sales include pre-arranged 10b5-1 plan sales.
  1. BBTXBought: Bambusa Therapeutics, Inc. Nov 2, 2026 2,500,000 shares filed Nov 3, 2026 2 transactions filing $40.0M
  2. BBTXBought: Bambusa Therapeutics, Inc. Oct 30, 2026 453,820 shares filed Nov 3, 2026 2 transactions filing $6.6M
  3. LENZSold: LENZ Therapeutics, Inc. Oct 29, 2026 2,718,684 shares filed Nov 2, 2026 3 transactions filing $9.1M
  4. SIONSold: Sionna Therapeutics, Inc. Sep 17, 2026 3,448,811 shares filed Sep 21, 2026 2 transactions filing $21.8M
  5. SEPNSold: Septerna, Inc. Aug 12, 2026 1,493,000 shares filed Aug 14, 2026 2 transactions filing $63.5M
  6. ARTVBought: Artiva Biotherapeutics, Inc. Jul 31, 2026 24,944 shares filed Jul 31, 2026 17,329,570 shares held indirectly after, as filed filing $248K
  7. ARTVBought: Artiva Biotherapeutics, Inc. Jul 29, 2026 20,824 shares filed Jul 31, 2026 17,304,626 shares held indirectly after, as filed filing $208K
  8. ARTVBought: Artiva Biotherapeutics, Inc. Jul 24, 2026 41,319 shares filed Jul 28, 2026 17,283,802 shares held indirectly after, as filed filing $413K
  9. ARTVBought: Artiva Biotherapeutics, Inc. Jul 23, 2026 59,880 shares filed Jul 23, 2026 17,242,483 shares held indirectly after, as filed filing $596K
  10. PBLSBought: Parabilis Medicines, Inc. Jul 22, 2026 47,250 shares filed Jul 22, 2026 26,529,686 shares held indirectly after, as filed filing $1.4M
  11. ARTVBought: Artiva Biotherapeutics, Inc. Jul 22, 2026 84,124 shares filed Jul 23, 2026 17,182,603 shares held indirectly after, as filed filing $835K
  12. PBLSBought: Parabilis Medicines, Inc. Jul 21, 2026 65,923 shares filed Jul 22, 2026 3 transactions filing $1.9M
  13. ARTVBought: Artiva Biotherapeutics, Inc. Jul 21, 2026 120,582 shares filed Jul 23, 2026 17,098,479 shares held indirectly after, as filed filing $1.2M
  14. PBLSBought: Parabilis Medicines, Inc. Jul 20, 2026 131,420 shares filed Jul 22, 2026 2 transactions filing $3.6M
  15. ARTVBought: Artiva Biotherapeutics, Inc. Jul 17, 2026 7,882 shares filed Jul 20, 2026 16,977,927 shares held indirectly after, as filed filing $71K
  16. ARTVBought: Artiva Biotherapeutics, Inc. Jul 16, 2026 152,472 shares filed Jul 20, 2026 16,970,045 shares held indirectly after, as filed filing $1.4M
  17. ARTVBought: Artiva Biotherapeutics, Inc. Jul 13, 2026 6,522 shares filed Jul 23, 2026 16,817,543 shares held indirectly after, as filed filing $58K
  18. ARTVBought: Artiva Biotherapeutics, Inc. Jul 10, 2026 15,102 shares filed Jul 14, 2026 16,811,021 shares held indirectly after, as filed filing $135K
  19. ARTVBought: Artiva Biotherapeutics, Inc. Jun 26, 2026 1,876 shares filed Jun 29, 2026 16,795,919 shares held indirectly after, as filed filing $17K
  20. ARTVBought: Artiva Biotherapeutics, Inc. Jun 25, 2026 31,000 shares filed Jun 29, 2026 16,794,043 shares held indirectly after, as filed filing $275K
  21. HOWLSold: Werewolf Therapeutics, Inc. Jun 17, 2026 416,911 shares filed Jun 22, 2026 2 transactions filing $146K
  22. COAGBought: Hemab Therapeutics Holdings, Inc. Jun 16, 2026 61,523 shares filed Jun 17, 2026 6,444,637 shares held indirectly after, as filed filing $1.5M
  23. ARTVBought: Artiva Biotherapeutics, Inc. Jun 16, 2026 124,893 shares filed Jun 16, 2026 16,763,043 shares held indirectly after, as filed filing $1.1M
  24. HOWLSold: Werewolf Therapeutics, Inc. Jun 16, 2026 149,625 shares filed Jun 16, 2026 2 transactions filing $55K
  25. COAGBought: Hemab Therapeutics Holdings, Inc. Jun 15, 2026 6,146 shares filed Jun 17, 2026 6,383,114 shares held indirectly after, as filed filing $153K
  26. ARTVBought: Artiva Biotherapeutics, Inc. Jun 15, 2026 15,414 shares filed Jun 16, 2026 16,638,150 shares held indirectly after, as filed filing $139K
  27. HOWLSold: Werewolf Therapeutics, Inc. Jun 15, 2026 128,770 shares filed Jun 16, 2026 2 transactions filing $50K
  28. ARTVBought: Artiva Biotherapeutics, Inc. Jun 12, 2026 391,019 shares filed Jun 16, 2026 16,622,736 shares held indirectly after, as filed filing $3.4M
  29. HOWLSold: Werewolf Therapeutics, Inc. Jun 12, 2026 170,441 shares filed Jun 16, 2026 2 transactions filing $68K
  30. PBLSBought: Parabilis Medicines, Inc. Jun 11, 2026 21,188,750 shares filed Jun 15, 2026 2 transactions filing $423.8M

Source: SEC Form 4 filings. Value is shares × the price reported on the filing; a filing whose price failed Lytir's check against the market price is left out, and a trade that related owners reported on separate forms is counted once. Filings can be late, amended or wrong at the source; see methodology.

Other Form 4 entries

Not counted above: entries this filer reported on Form 4 in the same 12 months that are not open-market purchases or sales. Each entry is one line of a filing.

  • FRNM: grant or award (code A), 7 entries, Jul 20, 2026
  • CLYM: option exercise or conversion (code M), 4 entries, Sep 28, 2026
  • BBTX: conversion (code C), 2 entries, Nov 2, 2026
  • PBLS: conversion (code C), 2 entries, Jun 11, 2026
  • VOR: option exercise or conversion (code M), 2 entries, Aug 24 to Oct 2, 2026
  • IKT: other acquisition or disposition (code J), 1 entry, Jul 29, 2026
  • VOR: in-the-money exercise (code X), 1 entry, Jul 16, 2026
  • WVE: grant or award (code A), 1 entry, Oct 5, 2026
Code A
A grant or award from the company, such as stock given as pay.
Code C
A conversion of a derivative security, such as preferred stock or units, into shares.
Code J
Another acquisition or disposition, described in the filing's footnotes.
Code M
An exercise or conversion of a derivative security received from the company, such as stock options.
Code X
An exercise of an in-the-money or at-the-money derivative security.

Source: the same SEC Form 4 filings. The codes are the SEC's own transaction codes; the meanings above are a plain-words reading of the SEC's Form 4 instructions.