LYTIR

Insider · SEC Form 4 · 10% Owner

Opaleye Management Inc.

In the 12 months to Nov 8, 2026, on the open market: bought $9.8M of ACOG, SLGL, GRCE; sold $5.8M of ETON. Filed a median of 1 business day after the trade.

Open-market purchases and sales this filer reported on SEC Form 4, by the day traded. Insiders have two business days to file. A sale marked 10b5-1 was made under a plan adopted in advance. How to read these

Insider purchases and sales, by month (last 12 months)Insider purchases: $9.8M in total; Insider sales: $5.8M in total.Jun: Insider purchases $1.0MJul: Insider purchases $1.9MJul: Insider sales $5.8MAug: Insider purchases $3.3MSep: Insider purchases $2.4MOct: Insider purchases $1.2MNov: Insider purchases $33KDecJanFebMarAprMayJunJulAugSepOctNov
Insider purchases above the line: $9.8MInsider sales below: $5.8M
Dollar value of open-market purchases and sales reported on SEC Form 4, by the month traded. Sales include pre-arranged 10b5-1 plan sales.
  1. GRCEBought: Grace Therapeutics, Inc. Nov 5, 2026 3,087 shares filed Nov 5, 2026 3,054,853 shares held indirectly after, as filed filing $5K
  2. GRCEBought: Grace Therapeutics, Inc. Nov 4, 2026 5,027 shares filed Nov 5, 2026 3,051,766 shares held indirectly after, as filed filing $9K
  3. GRCEBought: Grace Therapeutics, Inc. Nov 3, 2026 10,328 shares filed Nov 5, 2026 3,046,739 shares held indirectly after, as filed filing $18K
  4. GRCEBought: Grace Therapeutics, Inc. Oct 26, 2026 66,411 shares filed Oct 26, 2026 3,036,411 shares held indirectly after, as filed filing $117K
  5. ACOGBought: Alpha Cognition Inc. Oct 23, 2026 14,973 shares filed Oct 26, 2026 3,291,984 shares held indirectly after, as filed filing $123K
  6. ACOGBought: Alpha Cognition Inc. Oct 22, 2026 17,117 shares filed Oct 26, 2026 3,277,011 shares held indirectly after, as filed filing $143K
  7. GRCEBought: Grace Therapeutics, Inc. Oct 22, 2026 21,390 shares filed Oct 26, 2026 2,970,000 shares held indirectly after, as filed filing $41K
  8. GRCEBought: Grace Therapeutics, Inc. Oct 19, 2026 4,256 shares filed Oct 21, 2026 2,948,610 shares held indirectly after, as filed filing $8K
  9. ACOGBought: Alpha Cognition Inc. Oct 16, 2026 14,283 shares filed Oct 19, 2026 3,259,894 shares held indirectly after, as filed filing $118K
  10. GRCEBought: Grace Therapeutics, Inc. Oct 16, 2026 36,347 shares filed Oct 16, 2026 2,944,354 shares held indirectly after, as filed filing $69K
  11. ACOGBought: Alpha Cognition Inc. Oct 15, 2026 22,657 shares filed Oct 19, 2026 3,245,611 shares held indirectly after, as filed filing $191K
  12. GRCEBought: Grace Therapeutics, Inc. Oct 15, 2026 23,485 shares filed Oct 16, 2026 2,908,007 shares held indirectly after, as filed filing $46K
  13. GRCEBought: Grace Therapeutics, Inc. Oct 14, 2026 11,233 shares filed Oct 16, 2026 2,884,522 shares held indirectly after, as filed filing $22K
  14. GRCEBought: Grace Therapeutics, Inc. Oct 12, 2026 7,215 shares filed Oct 13, 2026 2,873,289 shares held indirectly after, as filed filing $15K
  15. GRCEBought: Grace Therapeutics, Inc. Oct 9, 2026 5,340 shares filed Oct 13, 2026 2,866,074 shares held indirectly after, as filed filing $11K
  16. GRCEBought: Grace Therapeutics, Inc. Oct 8, 2026 2,077 shares filed Oct 13, 2026 2,860,734 shares held indirectly after, as filed filing $4K
  17. GRCEBought: Grace Therapeutics, Inc. Oct 5, 2026 1,694 shares filed Oct 5, 2026 2,858,657 shares held indirectly after, as filed filing $3K
  18. GRCEBought: Grace Therapeutics, Inc. Oct 2, 2026 20,000 shares filed Oct 5, 2026 2,856,963 shares held indirectly after, as filed filing $41K
  19. ACOGBought: Alpha Cognition Inc. Oct 1, 2026 19,050 shares filed Oct 2, 2026 3,222,954 shares held indirectly after, as filed filing $166K
  20. GRCEBought: Grace Therapeutics, Inc. Oct 1, 2026 38,796 shares filed Oct 5, 2026 2,836,963 shares held indirectly after, as filed filing $79K
  21. GRCEBought: Grace Therapeutics, Inc. Sep 29, 2026 7,849 shares filed Oct 1, 2026 2,798,167 shares held indirectly after, as filed filing $16K
  22. ACOGBought: Alpha Cognition Inc. Sep 25, 2026 13,426 shares filed Sep 28, 2026 3,203,904 shares held indirectly after, as filed filing $114K
  23. ACOGBought: Alpha Cognition Inc. Sep 24, 2026 18,337 shares filed Sep 28, 2026 3,190,478 shares held indirectly after, as filed filing $157K
  24. GRCEBought: Grace Therapeutics, Inc. Sep 23, 2026 5,318 shares filed Oct 1, 2026 2,790,318 shares held indirectly after, as filed filing $11K
  25. GRCEBought: Grace Therapeutics, Inc. Sep 21, 2026 9,771 shares filed Oct 1, 2026 2,785,000 shares held indirectly after, as filed filing $21K
  26. ACOGBought: Alpha Cognition Inc. Sep 16, 2026 80,170 shares filed Sep 16, 2026 2 transactions filing $683K
  27. ACOGBought: Alpha Cognition Inc. Sep 15, 2026 3,375 shares filed Sep 16, 2026 3,091,971 shares held indirectly after, as filed filing $29K
  28. ACOGBought: Alpha Cognition Inc. Sep 14, 2026 40,373 shares filed Sep 16, 2026 3,088,596 shares held indirectly after, as filed filing $351K
  29. SLGLBought: Sol-Gel Technologies Ltd. Sep 11, 2026 1,493 shares filed Sep 14, 2026 540,000 shares held indirectly after, as filed filing $98K
  30. SLGLBought: Sol-Gel Technologies Ltd. Sep 10, 2026 1,631 shares filed Sep 14, 2026 538,507 shares held indirectly after, as filed filing $109K
  31. SLGLBought: Sol-Gel Technologies Ltd. Sep 9, 2026 3,097 shares filed Sep 9, 2026 536,876 shares held indirectly after, as filed filing $213K
  32. GRCEBought: Grace Therapeutics, Inc. Sep 9, 2026 5,836 shares filed Sep 10, 2026 2,775,229 shares held indirectly after, as filed filing $12K
  33. SLGLBought: Sol-Gel Technologies Ltd. Sep 8, 2026 3,861 shares filed Sep 9, 2026 2 transactions filing $266K
  34. GRCEBought: Grace Therapeutics, Inc. Sep 8, 2026 9,393 shares filed Sep 10, 2026 2,769,393 shares held indirectly after, as filed filing $20K
  35. SLGLBought: Sol-Gel Technologies Ltd. Sep 4, 2026 3,018 shares filed Sep 9, 2026 2 transactions filing $209K
  36. SLGLBought: Sol-Gel Technologies Ltd. Sep 2, 2026 900 shares filed Sep 3, 2026 526,900 shares held indirectly after, as filed filing $62K
  37. SLGLBought: Sol-Gel Technologies Ltd. Sep 1, 2026 783 shares filed Sep 3, 2026 526,000 shares held indirectly after, as filed filing $54K
  38. SLGLBought: Sol-Gel Technologies Ltd. Aug 31, 2026 5,217 shares filed Aug 31, 2026 2 transactions filing $356K
  39. SLGLBought: Sol-Gel Technologies Ltd. Aug 28, 2026 35,113 shares filed Aug 31, 2026 3 transactions filing $2.4M
  40. GRCEBought: Grace Therapeutics, Inc. Aug 14, 2026 11,608 shares filed Aug 19, 2026 2,760,000 shares held indirectly after, as filed filing $24K
  41. SLGLBought: Sol-Gel Technologies Ltd. Aug 12, 2026 951 shares filed Aug 14, 2026 494,887 shares held indirectly after, as filed filing $68K
  42. ACOGBought: Alpha Cognition Inc. Aug 3, 2026 50,000 shares filed Aug 4, 2026 3,048,223 shares held indirectly after, as filed filing $400K
  43. ACOGBought: Alpha Cognition Inc. Jul 31, 2026 2,900 shares filed Aug 4, 2026 2,998,223 shares held indirectly after, as filed filing $23K
  44. ACOGBought: Alpha Cognition Inc. Jul 24, 2026 130 shares filed Jul 28, 2026 2,995,323 shares held indirectly after, as filed filing $1K
  45. ACOGBought: Alpha Cognition Inc. Jul 23, 2026 49,849 shares filed Jul 24, 2026 2,995,193 shares held indirectly after, as filed filing $389K
  46. ACOGBought: Alpha Cognition Inc. Jul 22, 2026 150,237 shares filed Jul 24, 2026 2 transactions filing $1.2M
  47. ETONSold: Eton Pharmaceuticals, Inc. Jul 14, 2026 28,315 shares filed Jul 17, 2026 2 transactions filing $1.1M
  48. SLGLBought: Sol-Gel Technologies Ltd. Jul 14, 2026 920 shares filed Jul 15, 2026 493,936 shares held indirectly after, as filed filing $68K
  49. SLGLBought: Sol-Gel Technologies Ltd. Jul 13, 2026 775 shares filed Jul 15, 2026 493,016 shares held indirectly after, as filed filing $57K
  50. SLGLBought: Sol-Gel Technologies Ltd. Jul 10, 2026 229 shares filed Jul 10, 2026 492,241 shares held indirectly after, as filed filing $17K
  51. SLGLBought: Sol-Gel Technologies Ltd. Jul 8, 2026 300 shares filed Jul 10, 2026 492,012 shares held indirectly after, as filed filing $22K
  52. ETONSold: Eton Pharmaceuticals, Inc. Jul 7, 2026 26,685 shares filed Jul 7, 2026 2 transactions filing $1.0M
  53. ETONSold: Eton Pharmaceuticals, Inc. Jul 6, 2026 10,000 shares filed Jul 7, 2026 2,700,000 shares held indirectly after, as filed filing $380K
  54. ETONSold: Eton Pharmaceuticals, Inc. Jul 2, 2026 90,000 shares filed Jul 7, 2026 2 transactions filing $3.4M
  55. SLGLBought: Sol-Gel Technologies Ltd. Jul 2, 2026 1,400 shares filed Jul 2, 2026 491,712 shares held indirectly after, as filed filing $101K
  56. SLGLBought: Sol-Gel Technologies Ltd. Jul 1, 2026 312 shares filed Jul 2, 2026 490,312 shares held indirectly after, as filed filing $22K
  57. ACOGBought: Alpha Cognition Inc. Jun 26, 2026 152,336 shares filed Jun 29, 2026 2,805,107 shares held indirectly after, as filed filing $975K
  58. ACOGBought: Alpha Cognition Inc. Jun 25, 2026 197 shares filed Jun 29, 2026 2,652,771 shares held indirectly after, as filed filing $1K
  59. ACOGBought: Alpha Cognition Inc. Jun 15, 2026 4,550 shares filed Jun 15, 2026 2,652,574 shares held indirectly after, as filed filing $27K
  60. ACOGBought: Alpha Cognition Inc. Jun 12, 2026 273 shares filed Jun 15, 2026 2,648,024 shares held indirectly after, as filed filing $2K
  61. ACOGBought: Alpha Cognition Inc. Jun 11, 2026 2,862 shares filed Jun 15, 2026 2,647,751 shares held indirectly after, as filed filing $17K

Source: SEC Form 4 filings. Value is shares × the price reported on the filing; a filing whose price failed Lytir's check against the market price is left out, and a trade that related owners reported on separate forms is counted once. Filings can be late, amended or wrong at the source; see methodology.